Green Calm QA
Nutritional Strategies for Supporting Neurovascular Comfort and Sensory Balance
Recurring head tension, sensory hypersensitivity, and mood-related discomfort can impact quality of life significantly. While the root cause is multifactorial, emerging science highlights the role of oxidative stress, neuroinflammation, mitochondrial dysfunction, and neurotransmitter imbalances.
Key biomarkers—such as CGRP, homocysteine, and markers of oxidative stress and neurotransmitter turnover—are increasingly recognized in these episodic discomfort patterns. Research now supports the use of select nutritional bioactives to modulate these pathways and help maintain neurological equilibrium.
Formulated for neurovascular comfort, emotional resilience, and sensory balance.
- Targets: CGRP regulation, neurotransmitter balance, mitochondrial stress
- Key Ingredients: CoQ10, Riboflavin, B6, B12, Folic Acid (5-MTHF), Vitamin C, Coriander
Coriandrum sativum (Coriander)
A traditional herb now studied for its sensory-modulating potential:
- Linalool, its primary volatile, modulates TRPM8 channels to help reduce nociceptive signaling
- Offers antioxidant protection by lowering MDA, 8-isoprostane, and boosting TAC
- May help calm sensory overactivation during neurovascular stress
Coenzyme Q10 (CoQ10)
Critical for cellular energy and mitochondrial support in sensitive neurons:
- Boosts ATP production and restores mitochondrial efficiency
- Lowers CGRP, CRP, TNF-α, and IL-6 to reduce neuroinflammatory markers
- Enhances neuronal resilience in energy-depleted states
Riboflavin (Vitamin B2)
Essential for mitochondrial enzyme complexes and antioxidant regeneration:
- Supports FAD/FMN coenzyme formation for optimal oxidative phosphorylation
- Enhances GPx activity and complex I & IV function
- Improves tolerance to episodic head discomfort linked to mitochondrial dysfunction
Vitamin B12 (Cobalamin)
Neuroprotective and essential for neurotransmitter regulation:
- Regulates homocysteine to protect vascular and neuronal integrity
- Supports serotonin and dopamine turnover—key for neurological calm
- Enhances 5-HIAA and dopamine metabolites for neurochemical balance
Vitamin B6 (Pyridoxine)
The coenzyme PLP is vital for mood and sensory regulation:
- Required for serotonin, dopamine, and GABA synthesis
- Low B6 leads to elevated kynurenine/tryptophan ratio (KTR) a biomarker of stress
- Helps maintain healthy tryptophan metabolism and sensory resilience
Folic Acid and 5-MTHF (Quatrefolic®)
A central nutrient in one-carbon metabolism and neurotransmitter methylation:
- Reduces homocysteine, supporting endothelial and neurovascular tone
- Aids in SAMe and catecholamine synthesis (dopamine, norepinephrine)
- 5-MTHF form ensures superior bioavailability, even in individuals with MTHFR polymorphism
Vitamin C (Ascorbic Acid)
A powerful antioxidant and neuromodulator:
- Scavenges ROS and reduces 8-OHdG, oxLDL, and F2-isoprostanes
- Supports blood-brain barrier integrity and BH4 regeneration
- Essential for serotonin and dopamine biosynthesis via cofactor recycling
Key Functional Ingredients
Together, these mechanisms support energy metabolism, chemical signaling, and oxidative defense restoring neurological balance and building resilience against recurring head stress.
Mitochondrial Optimization
CoQ10 and riboflavin enhance mitochondrial electron transport and ATP production, ensuring energy supply to sensitive neuronal tissues.
Neurotransmitter Synthesis & Regulation
Active forms of B-vitamins (B6, B12, 5-MTHF) support the synthesis of serotonin, dopamine, and GABA—neurochemicals essential for mood regulation and sensory stability.
Homocysteine Clearance
Elevated homocysteine is a known vascular irritant. The B-vitamin triad (B6, B12, folate) helps reduce homocysteine, preserving endothelial tone and cerebral circulation.
CGRP and Sensory Modulation
Coriander extract (rich in linalool) modulates TRP channels and supports CGRP balance—key mediators in neurogenic inflammation and sensory amplification.
Oxidative Stress Control
Vitamin C and CoQ10 act as antioxidants, protecting neuronal membranes and vasculature from free radical damage that can trigger episodic discomfort.
Mechanism of Action: Why It Works
This formulation targets the interconnected biological systems responsible for neurovascular balance and episodic head discomfort.
The Greenspace Approach to Neurovascular Comfort
At Greenspace, we see neurological wellness as a reflection of systemic balance—not just the absence of discomfort. Recurring neurovascular episodes often signal deeper physiological shifts, including oxidative overload, mitochondrial fatigue, and neurotransmitter dysregulation.
That’s why our formulation strategy is both rooted in nature and refined by science—addressing these complexities through precision nutraceutical design.
Because neurovascular comfort isn’t just about fewer episodes it’s about stronger clarity, deeper calm, and a better quality of life.
Multi-pathway precision
Each ingredient is selected to target a specific axis of neurovascular balance energy, inflammation, neurotransmission, or oxidative control.
Clinically aligned ingredients
We focus on nutrients supported by biomarker-driven research, with known actions on CGRP, homocysteine, KTR, GPx, and more.
Bioavailable, clean-label formulations
We use forms like 5-MTHF and active B6 to maximize impact, without fillers, dyes, or unnecessary synthetics.
Restorative, not reactive
Our goal is to build resilience supporting your body’s ability to self-regulate, self-repair, and restore calm from within.
A New Era of Healing Begins Here ...
At Greenspace, our foundation rests on a bold vision: to advance Ayurveda into its most powerful evolution yet—Quantum Ayurveda. This is not a rebranding of tradition. This is a scientific transformation. A merging of ancient energetic wisdom with modern quantum biology, artificial intelligence, and systems-level clinical validation.